Bone Abstracts

Bone marrow is composed of cells developed within the marrow compartment as well as blood supplied from the general circulation. Bone tissue is affected by cytokines within the bone marrow.We investigated if the levels of different bone acting cytokines differ between bone marrow and blood from the peripheral circulation.Fifty-three healthy postmenopausal women participated in a study designed to evaluate the effect of rosiglitazon...

Transforming growth factor (TGF)-β1 is the most abundant growth factor in human bone. Several polymorphisms have been described in the TGF-β1 gene (TGFB1). We have previously shown that individuals with the CC genotype of the T29C polymorphism have higher bone mass at the femoral neck. The T29C polymorphism causes a change from leucine to proline at codon 10, which is located in the hydrophobic α-helical part of the signal peptide....

Osteoporosis is a common disorder with a partly genetic pathogenesis. Interaction between RANKL and its receptor RANK is essential in bone remodeling.We therefore investigated the effect of polymorphisms in the RANK and RANKL genes and interaction between the effects on bone mineral density (BMD) and vertebral fractures.The study was a case-control study with 462 osteoporotic patients and 336 controls. Ten polymor...

Osteogenesis imperfecta refers to a group of inherited disorders characterised by increased bone fragility, low bone mass and fragility fractures. Most patients carry mutations in the genes that encode type I collagen or other proteins involved in its post-translational modification. Bisphosphonates are widely used in the treatment of osteogenesis imperfecta but clinical trials have been powered to detect effects on BMD rather than fracture. In order to gain better understandi...

Background: Clinical studies suggest that vitamin K2 prevents bone loss and may protect against fractures. Vitamin K is a cofactor in the carboxylation of Osteocalcin (OC). Carboxylated OC promotes mineralization of bone. The aim of the study was to investigate the effect of vitamin K2 on osteocalcin, bone mass and -quality.Methods: We conducted a randomized placebo-controlled double-blinded clinical trial, in which 142 postmenopausal osteopenic women we...

Introduction: Low 25-hydroxyvitamin D (25OHD) levels are frequently found in fertile women and associated with low birth weight, reduced fertility and adverse pregnancy outcomes.Objective: We investigated the effects of vitamin D supplementation on birth weight, fertility, and delivery complications in women planning pregnancy with low 25OHD levels.Methods: This was an investigator-initiated double-blind, randomized, placebo-contro...

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Purpose: Denosumab is commonly used as an anti-resorptive agent to treat osteoporosis. After discontinuation of denosumab, however, bone resorption increases again, and the bone mass gained during therapy is lost within a year.Methods: We present a case report of asymptomatic hypoparathyroid hypercalcemia in a patient who discontinued long-term treatment with denosumab.Results: A 67-year old women with osteoporosis was treated with...

Background: Resveratrol (RSV), a natural polyphenolic compound, stimulates osteoblasts and inhibits osteoclast activation in vitro. Conflicting results have emerged from short-term studies in rodents but a recent study in men suggests a positive effect on BMD.Aim: To evaluate effects of short- and long-term high-dose RSV supplementation on bone in immobilized and non-immobilized rats.Methods: A total of 72 female Wistar ra...

Osteogenesis imperfecta (OI) is a systemic connective tissue caused by mutations in collagen type 1 related genes. Patients with OI suffer from multiple fractures and various degrees of growth deficiency and bone deformity. Other symptoms are early hearing loss, abnormal dental tissue and hypermobility. It is not known whether the systemic effect of a defect collagen type 1 influences the quality of life in people with OI. We aimed to investigate health related quality of life...